Tooth Pain That Does Not Go Away: Could It Be Orofacial Pain? Tooth pain is often caused by a dental problem such as decay, infection, or inflammation.However, some people continue to have pain even after dental treatment, or they have pain without a clear dental cause. If your tooth pain does not go away or keeps coming back, it may be helpful to consider a comprehensive evaluation of orofacial regions, including the head, face, temporomandibular joints, and jaw muscles. In